Journal Article

FZJ-2021-03237

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being

Wolf, S. ; Becker, J. ; Tsuge, Y. ; Kawaguchi, H. ; Kondo, A. ; Marienhagen, J.FZJ* ; Bott, M.FZJ* ; Wendisch, V. F. ; Wittmann, C. (Corresponding author)

2021
Portland Press London

This record in other databases:      

Please use a persistent id in citations: http://hdl.handle.net/2128/28480  doi:10.1042/EBC20200134

Abstract: The soil microbe Corynebacterium glutamicum is a leading workhorse in industrial biotechnology and has become famous for its power to synthetise amino acids and a range of bulk chemicals at high titre and yield. The product portfolio of the microbe is continuously expanding. Moreover, metabolically engineered strains of C. glutamicum produce more than 30 high value active ingredients, including signature molecules of raspberry, savoury, and orange flavours, sun blockers, anti-ageing sugars, and polymers for regenerative medicine. Herein, we highlight recent advances in engineering of the microbe into novel cell factories that overproduce these precious molecules from pioneering proofs-of-concept up to industrial productivity.

Note: Biotechnologie 1

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Contributing Institute(s):

1. Biotechnologie (IBG-1)

Research Program(s):

1. 2172 - Utilization of renewable carbon and energy sources and engineering of ecosystem functions (POF4-217) (POF4-217)

Appears in the scientific report 2021

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Database coverage:
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