Journal Article

FZJ-2021-04251

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

Nguyen, P. H. ; Ramamoorthy, A. ; Sahoo, B. R. ; Zheng, J. ; Faller, P. ; Straub, J. E. ; Dominguez, L. ; Shea, J.-E. ; Dokholyan, N. V. ; De Simone, A. ; Ma, B. ; Nussinov, R. ; Najafi, S. ; Ngo, S. T. ; Loquet, A. ; Chiricotto, M. ; Ganguly, P. ; McCarty, J. ; Li, M. S. ; Hall, C. ; Wang, Y. ; Miller, Y. ; Melchionna, S. ; Habenstein, B. ; Timr, S. ; Chen, J. ; Hnath, B. ; Strodel, B.FZJ* ; Kayed, R. ; Lesné, S. ; Wei, G. ; Sterpone, F. ; Doig, A. J. ; Derreumaux, P. (Corresponding author)

2021
ACS Publ. Washington, DC

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Please use a persistent id in citations: http://hdl.handle.net/2128/30438  doi:10.1021/acs.chemrev.0c01122

Abstract: Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting either the central nervous system or a variety of peripheral tissues. Structural and dynamic characterization of all species along the pathways from monomers to fibrils is challenging by experimental and computational means because they involve intrinsically disordered proteins in most diseases. Yet understanding how amyloid species become toxic is the challenge in developing a treatment for these diseases. Here we review what computer, in vitro, in vivo, and pharmacological experiments tell us about the accumulation and deposition of the oligomers of the (Aβ, tau), α-synuclein, IAPP, and superoxide dismutase 1 proteins, which have been the mainstream concept underlying Alzheimer’s disease (AD), Parkinson’s disease (PD), type II diabetes (T2D), and amyotrophic lateral sclerosis (ALS) research, respectively, for many years.

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Contributing Institute(s):

1. Strukturbiochemie (IBI-7)

Research Program(s):

1. 5244 - Information Processing in Neuronal Networks (POF4-524) (POF4-524)

Appears in the scientific report 2021

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Database coverage:
; ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 50 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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