Journal Article

FZJ-2021-05941

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Cortical [18F]PI‐2620 Binding Differentiates Corticobasal Syndrome Subtypes

Palleis, C. ; Brendel, M. ; Finze, A. ; Weidinger, E. ; Bötzel, K. ; Danek, A. ; Beyer, L. ; Nitschmann, A. ; Kern, M. ; Biechele, G. ; Rauchmann, B.-S. ; Häckert, J. ; Höllerhage, M. ; Stephens, A. W. ; Drzezga, A.FZJ* ; Eimeren, T. ; Villemagne, V. L. ; Schildan, A. ; Barthel, H. ; Patt, M. ; Sabri, O. ; Bartenstein, P. ; Perneczky, R. ; Haass, C. ; Levin, J. (Corresponding author) ; Höglinger, G. U. (Corresponding author)

2021
Wiley New York, NY

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Please use a persistent id in citations: http://hdl.handle.net/2128/32246  doi:10.1002/mds.28624

Abstract: Background: Corticobasal syndrome is associated with cerebral protein aggregates composed of 4-repeat (~50% of cases) or mixed 3-repeat/4-repeat tau isoforms (~25% of cases) or nontauopathies (~25% of cases).Objectives: The aim of this single-center study was to investigate the diagnostic value of the tau PET-ligand [18 F]PI-2620 in patients with corticobasal syndrome.Methods: Forty-five patients (71.5 ± 7.6 years) with corticobasal syndrome and 14 age-matched healthy controls underwent [18 F]PI-2620-PET. Beta-amyloid status was determined by cerebral β-amyloid PET and/or CSF analysis. Subcortical and cortical [18 F]PI-2620 binding was quantitatively and visually compared between β-amyloid-positive and -negative patients and controls. Regional [18 F]PI-2620 binding was correlated with clinical and demographic data.Results: Twenty-four percent (11 of 45) were β-amyloid-positive. Significantly elevated [18 F]PI-2620 distribution volume ratios were observed in both β-amyloid-positive and β-amyloid-negative patients versus controls in the dorsolateral prefrontal cortex and basal ganglia. Cortical [18 F]PI-2620 PET positivity was distinctly higher in β-amyloid-positive compared with β-amyloid-negative patients with pronounced involvement of the dorsolateral prefrontal cortex. Semiquantitative analysis of [18 F]PI-2620 PET revealed a sensitivity of 91% for β-amyloid-positive and of 65% for β-amyloid-negative cases, which is in excellent agreement with prior clinicopathological data. Regardless of β-amyloid status, hemispheric lateralization of [18 F]PI-2620 signal reflected contralateral predominance of clinical disease severity.Conclusions: Our data indicate a value of [18 F]PI-2620 for evaluating corticobasal syndrome, providing quantitatively and regionally distinct signals in β-amyloid-positive as well as β-amyloid-negative corticobasal syndrome. In corticobasal syndrome, [18 F]PI-2620 may potentially serve for a differential diagnosis and for monitoring disease progression. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.Keywords: Alzheimer's disease; PET; corticobasal syndrome; four-repeat tauopathies; tau.

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Contributing Institute(s):

1. Molekulare Organisation des Gehirns (INM-2)

Research Program(s):

1. 5253 - Neuroimaging (POF4-525) (POF4-525)

Appears in the scientific report 2022

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