Journal Article

FZJ-2021-05957

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Task-evoked simultaneous FDG-PET and fMRI data for measurement of neural metabolism in the human visual cortex

Jamadar, S. D. (Corresponding author) ; Zhong, S. ; Carey, A. ; McIntyre, R. ; Ward, P. G. D. ; Fornito, A. ; Premaratne, M. ; Shah, N. J.FZJ* ; O’Brien, K. ; Stäb, D. ; Chen, Z. ; Egan, G. F.

2021
Nature Publ. Group London

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Please use a persistent id in citations: http://hdl.handle.net/2128/29994  doi:10.1038/s41597-021-01042-2

Abstract: Understanding how the living human brain functions requires sophisticated in vivo neuroimaging technologies to characterise the complexity of neuroanatomy, neural function, and brain metabolism. Fluorodeoxyglucose positron emission tomography (FDG-PET) studies of human brain function have historically been limited in their capacity to measure dynamic neural activity. Simultaneous [18 F]-FDG-PET and functional magnetic resonance imaging (fMRI) with FDG infusion protocols enable examination of dynamic changes in cerebral glucose metabolism simultaneously with dynamic changes in blood oxygenation. The Monash vis-fPET-fMRI dataset is a simultaneously acquired FDG-fPET/BOLD-fMRI dataset acquired from n = 10 healthy adults (18–49 yrs) whilst they viewed a flickering checkerboard task. The dataset contains both raw (unprocessed) images and source data organized according to the BIDS specification. The source data includes PET listmode, normalization, sinogram and physiology data. Here, the technical feasibility of using opensource frameworks to reconstruct the PET listmode data is demonstrated. The dataset has significant re-use value for the development of new processing pipelines, signal optimisation methods, and to formulate new hypotheses concerning the relationship between neuronal glucose uptake and cerebral haemodynamics.

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Contributing Institute(s):

1. Physik der Medizinischen Bildgebung (INM-4)
2. Jara-Institut Quantum Information (INM-11)
3. Jülich-Aachen Research Alliance - Translational Brain Medicine (JARA-BRAIN)

Research Program(s):

1. 5253 - Neuroimaging (POF4-525) (POF4-525)

Appears in the scientific report 2021

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