Journal Article

FZJ-2022-01305

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Brain volume patterns in corticobasal syndrome versus idiopathic Parkinson's disease

Ferrea, S. (Corresponding author) ; Junker, F. B. ; Hartmann, C. J. ; Dinkelbach, L. ; Eickhoff, S. B.FZJ* ; Moldovan, A. S. ; Südmeyer, M. ; Schnitzler, A. ; Schmidt-Wilcke, T.

2022
Wiley-Blackwell Berlin [u.a.]

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Please use a persistent id in citations: http://hdl.handle.net/2128/31549  doi:10.1111/jon.12971

Abstract: AbstractBackground and purpose: Patients with a corticobasal syndrome (CBS) present a rare form of atypical parkinsonism characterized by asymmetric clinical symptoms and progressive motor and nonmotor impairment, such as apraxia, alien limb phenomenon, aphasia, myoclonus, dystonia, and cognitive impairment. At early stages, clinical differentiation between CBS and idiopathic Parkinson's disease (IPD) can be challenging.Methods: Using high-resolution T1-weighted images and voxel-based morphometry (VBM), we sought to identify disease-specific patterns of brain atrophy in a small sample of CBS and IPD patients at early stages of disease. We acquired MR images of 17 patients diagnosed with CBS and compared them with MR images of 17 subjects affected by IPD. Images were preprocessed and analyzed using VBM.Results: When compared to each other, the CBS and IPD patients of our cohort showed differences in regional gray and white matter volume depending on the diagnosis, specifically in the superior longitudinal fascicle.Conclusions: In our small patients' group, VBM was able to detect changes in regional gray and white matter volume between patients affected by CBS and patients with IPD as early as 1.5-2 years after the onset of the first motor symptoms.Keywords: Corticobasal syndrome; brain atrophy; idiopathic Parkinson syndrome; voxel-based morphometry.

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Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 5252 - Brain Dysfunction and Plasticity (POF4-525) (POF4-525)

Appears in the scientific report 2022

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Database coverage:
; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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