Journal Article

FZJ-2022-01944

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Regional changes of brain structure during progression of idiopathic Parkinson's disease – A longitudinal study using deformation based morphometry

Pieperhoff, P. (Corresponding author)FZJ* ; Südmeyer, M. ; Dinkelbach, L. ; Hartmann, C. J. ; Ferrea, S. ; Moldovan, A. S. ; Minnerop, M.FZJ* ; Diaz-Pier, S.FZJ* ; Schnitzler, A. ; Amunts, K.FZJ*

2022
Elsevier New York, NY

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Please use a persistent id in citations: http://hdl.handle.net/2128/31051  doi:10.1016/j.cortex.2022.03.009

Abstract: Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder with a broad spectrum of motor and non-motor symptoms. The neuropathological characteristics of idiopathic PD are the degeneration of dopaminergic neurons in the striatum, and the propagation of aggregates of misfolded α-synuclein in the brain following a specific pattern (Braak et al., 2006). The relationship of this pattern with motor and cognitive symptoms is still equivocal. Therefore, we investigated longitudinally the spatio-temporal patterns of atrophy propagation in PD, their inter-individual variability and associations with clinical symptoms. Magnetic resonance (MR) images of 37 PD patients and 27 controls were acquired at up to 15 time-points per subject, and over observation periods of up to 8.8 years (mean: 3.7 years). MR images were analyzed by Deformation-based Morphometry to measure region volumes and their longitudinal changes. Differences of these regional volume data between patients and controls and their associations with clinical symptoms were calculated.

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Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)
2. Jülich Supercomputing Center (JSC)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)
2. HBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539) (945539)
3. HBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907) (785907)

Appears in the scientific report 2022

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