Poster (After Call)

FZJ-2022-03029

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Modeling spiking networks with neuron-glia interactions in NEST

Jiang, H.-J.FZJ* ; Aćimović, J. ; Manninen, T. ; Stapmanns, J.FZJ* ; Lehtimäki, M. ; Linne, M.-L. ; Diesmann, M.FZJ* ; van Albada, S. J. (Corresponding author)FZJ*

2022

Please use a persistent id in citations: http://hdl.handle.net/2128/31637

Abstract: Recent experimental evidence suggests an active roles of astrocytes in a number of brain functions and demon-strates coordinated neuronal and astrocytic activity in vivo [1]. In the cortex, astrocytes form non-overlappingdomains, each containing several hundreds of neurons and ~100,000 synapses [2]. Astrocytic processes arein close contact with synaptic terminals and affect synaptic transmission, plasticity, and neuronal excitability[3, 4]. Understanding the role of astrocytic mechanisms in brain functions and dysfunctions requires open-access tools for model implementation, simulation, and analysis. In the past decade, hundreds of new modelswith some form of neuron-astrocyte interaction dynamics have been proposed. However, their implementa-tion is rarely shared and not sufficiently documented to reproduce the findings [4, 5]. We developed a newmodule in the NEST simulator that allows efficient implementation and simulation of large neuron-astrocytepopulations. This includes an astrocyte model with internal calcium dynamics, a synapse model to commu-nicate between astrocytes and postsynaptic neurons, and user-friendly and efficient high-level connectivityfunctions, which allow probabilistic or deterministic pairing of neurons and astrocytes. This new module willimprove the convenience, reliability, and reproducibility of computational studies involving neuron-astrocyteinteractions.

Note: References[1] Lines J et al. (2020) Astrocytes modulate sensory-evoked neuronal network activity. Nat Commun. 11:3689.doi:10.1038/s41467-020-17536-3.[2] Zisis E et al (2021) Digital reconstruction of the neuro-glia-vascular architecture. Cereb. Cortex, 2021;00:1-18[3] Bazargani N and Attwell D. (2016) Astrocyte calcium signaling: the third wave. Nat. Neurosci. 19(2):182-9.doi: 10.1038/nn.4201[4] Linne M-L et al. (2022) Neuron–Glia Interactions and Brain Circuits. In: Giugliano, M., Negrello, M.,Linaro, D. (eds) Computational Modelling of the Brain. Advances in Experimental Medicine and Biology, vol1359. Springer, Cham. https://doi.org/10.1007/978-3-030-89439-9_4[5] Manninen T et al. (2018) Front. Neuroinf. 12:20. doi.org/10.3389/fninf.2018.00020

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Contributing Institute(s):

1. Jara-Institut Brain structure-function relationships (INM-10)
2. Computational and Systems Neuroscience (INM-6)
3. Theoretical Neuroscience (IAS-6)

Research Program(s):

1. 5231 - Neuroscientific Foundations (POF4-523) (POF4-523)
2. HBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539) (945539)

Appears in the scientific report 2022

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Database coverage:

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