Journal Article

FZJ-2022-03280

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Brain Morphometry Associated With Response to Levodopa and Deep Brain Stimulation in Parkinson Disease

Jergas, H. (Corresponding author) ; Petry-Schmelzer, J. N. ; Dembek, T. A. ; Dafsari, H. S. ; Visser-Vandewalle, V. ; Fink, G. R.FZJ* ; Baldermann, J. C. ; Barbe, M. T.

2023
Elsevier Amsterdam

This record in other databases:      

Please use a persistent id in citations: doi:10.1016/j.neurom.2022.01.013  doi:10.34734/FZJ-2022-03280

Abstract: ObjectivesWhether treatment response in patients with Parkinson disease depends on brain atrophy is insufficiently understood. The goal of this study is to identify specific atrophy patterns associated with response to dopaminergic therapy and deep brain stimulation.Materials and MethodsIn this study, we analyzed the association of gray matter brain atrophy patterns, as identified by voxel-based morphometry, with acute response to levodopa (N = 118) and subthalamic nucleus deep brain stimulation (N = 39). Motor status was measured as a change in points on the Unified Parkinson’s Disease Rating Scale III score. Baseline values were obtained before surgery, after cessation of dopaminergic medication for at least 12 hours; response to medication was assessed after administration of a standardized dose of levodopa. Response to deep brain stimulation was measured three months after surgery in the clinical condition after withdrawal of dopaminergic medication.ResultsAlthough frontoparietal brain gray matter loss was associated with subpar response to deep brain stimulation, there was no significant link between brain atrophy and response to levodopa.ConclusionWe conclude that response to deep brain stimulation relies on gray matter integrity; hence, gray matter loss may present a risk factor for poor response to deep brain stimulation and may be considered when making decision regarding clinical practice.

---

Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)

Appears in the scientific report 2023

---

Database coverage:
; ; Clarivate Analytics Master Journal List ; DEAL Wiley ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---