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| Home > Publications database > Cross-ethnicity/race generalization failure of RSFC-based behavioral prediction and potential consequences |
| Home > Publications database > Cross-ethnicity/race generalization failure of RSFC-based behavioral prediction and potential consequences |
| Poster (Other) | FZJ-2022-03783 |
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2022
Please use a persistent id in citations: http://hdl.handle.net/2128/32112
Abstract: Machine learning (ML) plays an important role in precision medicine. However, algorithmic biases that favor majority populations pose a key challenge to ML applications (Chouldechova 2018; Martin 2019; Obermeyer 2019). In neuroimaging, there is growing interest in the prediction of behavioral phenotypes based on resting-state functional connectivity (RSFC; Finn 2015, 2021; Greene 2018). But prediction biases/unfairness in this context were not assessed in the literature. Especially, predictive models were typically built by capitalizing on large cohorts with mixed ethnic group, in which the proportions of certain ethnical groups, e.g. African Americans (AA), are limited. Whether the models perform equally well across different ethnic groups was unclear. By using two large-scale neuroimaging datasets from the United States, we compared the prediction accuracy between AA and white Americans (WA) when ML models were trained on different composition of ethnic groups. We observed larger prediction errors in AA than WA for most behavioral measures, which was only limitedly affected by the composition of training population. We also investigated potential downstream consequences of biased predictions of behavioral phenotypes if they were used uncritically.
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