Journal Article

FZJ-2022-03966

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Control theory illustrates the energy efficiency in the dynamic reconfiguration of functional connectivity

Deng, S. ; Li, J.FZJ* ; Thomas Yeo, B. T. ; Gu, S. (Corresponding author)

2022
Springer Nature London

This record in other databases:      

Please use a persistent id in citations: http://hdl.handle.net/2128/32313  doi:10.1038/s42003-022-03196-0

Abstract: The brain's functional connectivity fluctuates over time instead of remaining steady in a stationary mode even during the resting state. This fluctuation establishes the dynamical functional connectivity that transitions in a non-random order between multiple modes. Yet it remains unexplored how the transition facilitates the entire brain network as a dynamical system and what utility this mechanism for dynamic reconfiguration can bring over the widely used graph theoretical measurements. To address these questions, we propose to conduct an energetic analysis of functional brain networks using resting-state fMRI and behavioral measurements from the Human Connectome Project. Through comparing the state transition energy under distinct adjacent matrices, we justify that dynamic functional connectivity leads to 60% less energy cost to support the resting state dynamics than static connectivity when driving the transition through default mode network. Moreover, we demonstrate that combining graph theoretical measurements and our energy-based control measurements as the feature vector can provide complementary prediction power for the behavioral scores (Combination vs. Control: t = 9.41, p = 1.64e-13; Combination vs. Graph: t = 4.92, p = 3.81e-6). Our approach integrates statistical inference and dynamical system inspection towards understanding brain networks.

---

Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)

Appears in the scientific report 2022

---

Database coverage:
; ; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

---