Gast ::
| Hauptseite > Publikationsdatenbank > Sex-related differences in cerebral A1 adenosine receptor availability in the human brain |
| Hauptseite > Publikationsdatenbank > Sex-related differences in cerebral A1 adenosine receptor availability in the human brain |
| Poster (After Call) | FZJ-2022-03968 |
; ; ; ; ; ; ; ; ; ; ;
2021
Please use a persistent id in citations: http://hdl.handle.net/2128/32690
Abstract: Introduction:Sex differences have been reported in terms of sleep duration, sleep efficiency, and sleep phases. Adenosine and its cerebral receptors, A1 adenosine receptor (A1AR) and A2A adenosine receptor (A2AAR), play an important role in homeostatic sleep-wake regulation. During wakefulness adenosine concentration increases, whereas it decreases during sleep. We investigated sex differences in the adenosine A1AR availability in human volunteers.Methods:We used the radioligand [18F]CPFPX combined with positron emission tomography to quantify brain A1AR availability in 50 volunteers (20 female, 30 male, 28 ± 5 years). Following a one-week ambulatory sleep satiation protocol (9 hours time in bed, TIB), scans were performed under well-rested conditions after at least three nights in the sleep lab with 8 hours TIB. The A1AR availability was estimated in terms of the [18F]CPFPX binding potential (BPND) via the Logan’s reference tissue model (t* = 30 min) based on average k2’, resulting from the simplified reference tissue model. The cerebellum was used as a reference region. With independent t-tests we compared BPND between males and females.Results:Grey matter was subdivided into 12 regions. BPND was regionally 12-29 % higher in females than in males. Notably, in females, BPND was significantly higher in all brain regions indicating higher A1AR availability in females. The differences in BPND were particularly noticeable in regions which belong to the limbic system or are closely associated with it, such as anterior cingulum (0.57 ± 0.11 in females, 0.45 ± 0.11 in males), hippocampus (0.55 ± 0.08 in females, 0.43 ± 0.11 in males), and amygdala (0.51 ± 0.10 in females, 0.41 ± 0.11 in males).Conclusion:Females compared to males have a higher A1AR availability in the human brain already under well-rested conditions, which could explain the known sex differences in habitual sleep duration.Acknowledgment:We thank all volunteers for participating in the studies, and Sylvia Köhler-Dibowski from the Forschungszentrum Jülich and Annette von Waechter of the German Aerospace Center for their excellent technical assistance and support in study conductance.
|
The record appears in these collections: |
PDF
Fulltext by OpenAccess repository