Journal Article

FZJ-2022-05584

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Horseradish Peroxidase-Based Biosensors with Different Nanotransducers for the Determination of Hydrogen Peroxide

Nikolaev, K. G. ; Ermakov, S. S. ; Ermolenko, Y. E. ; Navolotskaya, D. V. ; Offenhäusser, A.FZJ* ; Mourzina, Y. (Corresponding author)FZJ*

2021
Springer Science + Business Media B.V Dordrecht [u.a.]

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Please use a persistent id in citations: doi:10.1134/S1061934821040080

Abstract: We studied methods of the in situ synthesis of gold nanostructures on the electrode surface and of the directed electrochemical synthesis of nanodendrites to create biosensors based on horseradish peroxidase. The effect of nanostructuring of the transducer surface and its subsequent modification on the electroanalytical characteristics of sensors for the determination of hydrogen peroxide was studied. The use of these methods can significantly improve the performance characteristics of the biosensors, such as the sensitivity coefficient, limit of detection, and stability in the range of micromolar and submicromolar concentrations of hydrogen peroxide. The electrodes modified by the in situ synthesis of nanostructures with subsequent treatment with Meerwein’s reagent, as well as ultramicroelectrodes prepared by directional electrochemical synthesis, show low limits of detection for hydrogen peroxide, 0.2 and 0.08 µM, and high sensitivity coefficients, 0.71 and 0.84 A M–1 cm–2, respectively.

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Contributing Institute(s):

1. Bioelektronik (IBI-3)

Research Program(s):

1. 5241 - Molecular Information Processing in Cellular Systems (POF4-524) (POF4-524)

Appears in the scientific report 2022

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Database coverage:
Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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