Talk (non-conference) (Invited)

FZJ-2022-05991

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Feedback modulation of neural manifolds in macaque primary visual cortex

Morales-Gregorio, A. (Corresponding author)FZJ*

2022

Abstract: High-dimensional brain activity is in many cases organized into lower-dimensional neuralmanifolds [1,2]. Feedback from V4 to V1 is known to mediate visual attention [3] andcomputational work has shown that it can also rotate neural manifolds in acontext-dependent manner [4]. However, whether feedback signals can modulate neuralmanifolds in vivo remains to be ascertained.Here, we studied the neural manifolds in macaque (Macaca mulatta) visual cortex duringresting state [5] and found two distinct high-dimensional clusters in the activity. The clusterswere primarily correlated with behavioral state (eye closure) and had distinct dimensionality.Granger causality analysis revealed that feedback from V4 to V1 was significantly strongerduring the eyes-open periods. Finally, spiking neuron model simulations confirmed thatsignals mimicking V4-to-V1 feedback can modulate neural manifolds. Taken together, thedata analysis and simulations suggest that feedback signals actively modulate neuralmanifolds in the visual cortex of the macaque.References:[1] Stringer et al. (2020). Nature 571, 361-365. 10.1038/s41586-019-1346-5[2] Singh et al. (2008). Journal of Vision 8(8), 11. 10.1167/8.8.11[3] Poort et al. (2012). Neuron 75 (1), 143-156. 10.1016/j.neuron.2012.04.032[4] Naumann et al. (2022). eLife 11, 76096. 10.7554/eLife.76096[5] Chen*, Morales-Gregorio* et al. (2022). Scientific Data 9 (1), 77. 10.1038/s41597-022-01180-1

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Contributing Institute(s):

1. Computational and Systems Neuroscience (INM-6)
2. Theoretical Neuroscience (IAS-6)
3. Jara-Institut Brain structure-function relationships (INM-10)

Research Program(s):

1. 5231 - Neuroscientific Foundations (POF4-523) (POF4-523)
2. HBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539) (945539)
3. SPP 2041 347572269 - Integration von Multiskalen-Konnektivität und Gehirnarchitektur in einem supercomputergestützten Modell der menschlichen Großhirnrinde (347572269) (347572269)
4. GRK 2416 - GRK 2416: MultiSenses-MultiScales: Neue Ansätze zur Aufklärung neuronaler multisensorischer Integration (368482240) (368482240)

Appears in the scientific report 2022

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