Journal Article

PreJuSER-9710

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Cytoarchitecture and Probabilistic Maps of the Human Posterior Insular Cortex.

Kurth, F.FZJ* ; Eickhoff, S. B.FZJ* ; Schleicher, A. ; Hoemke, L.FZJ* ; Zilles, K.FZJ* ; Amunts, K.FZJ*

2010
Oxford Univ. Press Oxford

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Please use a persistent id in citations: doi:10.1093/cercor/bhp208

Abstract: The human posterior insula was shown to respond to a wide variety of stimulation paradigms (e.g. pain, somatosensory, or auditory processing) in functional imaging experiments. Although various anatomical maps of this region have been published over the last century, these schemes show variable results. Moreover, none can directly be integrated with functional imaging data. Hence, our current knowledge about the structure-function relationships in this region remains limited. We therefore remapped the posterior part of the human insular cortex in 10 postmortem brains using an observer-independent approach. This analysis revealed the existence of 3 cytoarchitectonically distinct areas in the posterior insula. The examined brains were then 3D reconstructed and spatially normalized to the Montreal Neurological Institute single-subject template. Probabilistic maps for each area were calculated by superimposing the individual delineations, and a cytoarchitectonic summary map was computed to chart the regional architectonic organization. These maps can be used to identify the anatomical correlates of functional activations observed in neuroimaging studies and to understand the microstructural correlates of the functional segregation of the human posterior insula.

Keyword(s): Adult (MeSH) ; Aged (MeSH) ; Aged, 80 and over (MeSH) ; Brain Mapping: methods (MeSH) ; Cerebral Cortex: cytology (MeSH) ; Cerebral Cortex: physiology (MeSH) ; Female (MeSH) ; Functional Laterality: physiology (MeSH) ; Humans (MeSH) ; Imaging, Three-Dimensional (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Models, Statistical (MeSH) ; Nerve Fibers, Myelinated: physiology (MeSH) ; Neural Pathways: anatomy & histology (MeSH) ; Neural Pathways: cytology (MeSH) ; Neural Pathways: physiology (MeSH) ; Neurons: cytology (MeSH) ; Neurons: physiology (MeSH) ; J ; areas (auto) ; dysgranular (auto) ; granular (auto) ; microstructure (auto) ; sensory (auto)

Note: Human Brain Project/Neuroinformatics research by the National Institute of Biomedical Imaging and Bioengineering; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Helmholtz Alliance "Systems Biology" the "Human Brain Model" (WP02 P03 to K. Z. and S. E.).

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Contributing Institute(s):

1. Molekulare Organisation des Gehirns (INM-2)
2. Strukturelle und funktionelle Organisation des Gehirns (INM-1)
3. Jülich-Aachen Research Alliance - Translational Brain Medicine (JARA-BRAIN)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (FUEK409) (FUEK409)
2. 89571 - Connectivity and Activity (POF2-89571) (POF2-89571)

Appears in the scientific report 2010

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