Journal Article

FZJ-2023-01645

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Simulations approaching data: cortical slow waves in inferred models of the whole hemisphere of mouse

Capone, C. (Corresponding author) ; De Luca, C. ; De Bonis, G. ; Gutzen, R.FZJ* ; Bernava, I. ; Pastorelli, E. ; Simula, F. ; Lupo, C. ; Tonielli, L. ; Resta, F. ; Allegra Mascaro, A. L. ; Pavone, F. ; Denker, M.FZJ* ; Paolucci, P. S.

2023
Springer Nature London

This record in other databases:      

Please use a persistent id in citations: http://hdl.handle.net/2128/34360  doi:10.1038/s42003-023-04580-0

Abstract: The development of novel techniques to record wide-field brain activity enables estimation of data-driven models from thousands of recording channels and hence across large regions of cortex. These in turn improve our understanding of the modulation of brain states and the richness of traveling waves dynamics. Here, we infer data-driven models from high-resolution in-vivo recordings of mouse brain obtained from wide-field calcium imaging. We then assimilate experimental and simulated data through the characterization of the spatio-temporal features of cortical waves in experimental recordings. Inference is built in two steps: an inner loop that optimizes a mean-field model by likelihood maximization, and an outer loop that optimizes a periodic neuro-modulation via direct comparison of observables that characterize cortical slow waves. The model reproduces most of the features of the non-stationary and non-linear dynamics present in the high-resolution in-vivo recordings of the mouse brain. The proposed approach offers new methods of characterizing and understanding cortical waves for experimental and computational neuroscientists.

---

Contributing Institute(s):

1. Computational and Systems Neuroscience (INM-6)
2. Theoretical Neuroscience (IAS-6)
3. Jara-Institut Brain structure-function relationships (INM-10)

Research Program(s):

1. 5231 - Neuroscientific Foundations (POF4-523) (POF4-523)
2. 5235 - Digitization of Neuroscience and User-Community Building (POF4-523) (POF4-523)
3. HBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539) (945539)
4. HBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907) (785907)

Appears in the scientific report 2023

---

Database coverage:
; ; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

---