Journal Article

FZJ-2023-02165

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Ubiquitous lognormal distribution of neuron densities in mammalian cerebral cortex

Morales-Gregorio, A. (Corresponding author)FZJ* ; van Meegen, A.FZJ* ; van Albada, S. J.FZJ*

2023
Oxford Univ. Press Oxford

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Please use a persistent id in citations: doi:10.1093/cercor/bhad160  doi:10.34734/FZJ-2023-02165

Abstract: Numbers of neurons and their spatial variation are fundamental organizational features of the brain. Despite the large corpus of cytoarchitectonic data available in the literature, the statistical distributions of neuron densities within and across brain areas remain largely uncharacterized. Here, we show that neuron densities are compatible with a lognormal distribution across cortical areas in several mammalian species, and find that this also holds true within cortical areas. A minimal model of noisy cell division, in combination with distributed proliferation times, can account for the coexistence of lognormal distributions within and across cortical areas. Our findings uncover a new organizational principle of cortical cytoarchitecture: the ubiquitous lognormal distribution of neuron densities, which adds to a long list of lognormal variables in the brain.

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Contributing Institute(s):

1. Computational and Systems Neuroscience (INM-6)
2. Theoretical Neuroscience (IAS-6)
3. Jara-Institut Brain structure-function relationships (INM-10)

Research Program(s):

1. 5231 - Neuroscientific Foundations (POF4-523) (POF4-523)
2. HBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539) (945539)
3. DFG project 347572269 - Heterogenität von Zytoarchitektur, Chemoarchitektur und Konnektivität in einem großskaligen Computermodell der menschlichen Großhirnrinde (347572269) (347572269)
4. HBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907) (785907)

Appears in the scientific report 2023

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