Journal Article

FZJ-2023-02432

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Gradients of neurotransmitter receptor expression in the macaque cortex

Froudist-Walsh, S. ; Xu, T. ; Niu, M.FZJ* ; Rapan, L. ; Zhao, L.FZJ* ; Margulies, D. S. ; Zilles, K. ; Wang, X.-J. ; Palomero-Gallagher, N. (Corresponding author)FZJ*

2023
Nature America New York, NY

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Please use a persistent id in citations: doi:10.1038/s41593-023-01351-2  doi:10.34734/FZJ-2023-02432

Abstract: Dynamics and functions of neural circuits depend on interactions mediated by receptors. Therefore, a comprehensive map of receptor organization across cortical regions is needed. In this study, we used in vitro receptor autoradiography to measure the density of 14 neurotransmitter receptor types in 109 areas of macaque cortex. We integrated the receptor data with anatomical, genetic and functional connectivity data into a common cortical space. We uncovered a principal gradient of receptor expression per neuron. This aligns with the cortical hierarchy from sensory cortex to higher cognitive areas. A second gradient, driven by serotonin 5-HT1A receptors, peaks in the anterior cingulate, default mode and salience networks. We found a similar pattern of 5-HT1A expression in the human brain. Thus, the macaque may be a promising translational model of serotonergic processing and disorders. The receptor gradients may enable rapid, reliable information processing in sensory cortical areas and slow, flexible integration in higher cognitive areas.

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Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)
2. HBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539) (945539)
3. HIBALL - Helmholtz International BigBrain Analytics and Learning Laboratory (HIBALL) (InterLabs-0015) (InterLabs-0015)
4. 3D-MMA - Gradienten der Verteilung multipler Transmitterrezeptoren in der Hirnrinde als Grundlage verteilter kognitiver, sensorischer und motorischer Funktionen. (01GQ1902) (01GQ1902)

Appears in the scientific report 2023

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Database coverage:
; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Nature ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 20 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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