Journal Article

FZJ-2024-00617

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Radiochemical isolation of 45Ti using ion chromatography

Strecker, J. (Corresponding author)FZJ* ; Wachten, T.FZJ* ; Neumaier, B.FZJ* ; Spahn, I.FZJ*

2024
Springer Science + Business Media B.V. Dordrecht [u.a.]

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Please use a persistent id in citations: doi:10.1007/s10967-023-09270-z  doi:10.34734/FZJ-2024-00617

Abstract: 45Ti exhibits favorable decay properties for positron emission tomography (PET) imaging and can be easily produced bythe bombardment of natural scandium (Sc) by protons using the 45Sc(p,n)45Ti nuclear reaction. However, separation of45Ti from irradiated Sc targets is arduous due to the hydrolytic instability of Ti(IV) complexes, making it a significant bottleneckfor routine application of this radionuclide. In the present work, we describe the development and optimization ofan ion chromatographic separation method based on trapping of 45Ti on a hydroxamate-functionalized chelating resin andsubsequent elution with oxalic acid at pH = 2.8. Under optimized conditions, this method enabled 45Ti-recovery of 61 ± 8%within 7 min. Sc contamination in scaled-up experiments was found to be only 3.0 ± 1.8 μg/mL. The resulting 45Ti-solutionwas directly used for complexation with CDTA as a model chelator, affording the corresponding [45Ti]Ti(cdta) complex witha radiochemical conversion of 73 ± 3%. Conclusively, this promising method could be transferred to automated synthesismodules and should enable the preparation of 45Ti-labeled compounds for PET imaging.

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Contributing Institute(s):

1. Nuklearchemie (INM-5)

Research Program(s):

1. 5253 - Neuroimaging (POF4-525) (POF4-525)

Appears in the scientific report 2024

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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