Journal Article

FZJ-2024-02675

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Broadening Application Spectrum of iDPC-STEM Imaging from Beam Sensitive Solid Materials to Biological and Cryo Nano-particles Using Single Particle Analysis

Lazić, I. (Corresponding author) ; Wirix, M. ; Mann, D.FZJ* ; Filopoulou, A.FZJ* ; Leidl, M. L.FZJ* ; Müller-Caspary, K.FZJ* ; Meingast, A. ; Carlsson, A. ; de Haas, F. ; Sachse, C.FZJ*

2023
Oxford University Press Oxford

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Please use a persistent id in citations: doi:10.1093/micmic/ozad067.142  doi:10.34734/FZJ-2024-02675

Abstract: In the recent years, scanning transmission electron microscopy (STEM) applying focused electron illumination, has been shown to have the capacity to image extremely electron beam sensitive materials [1, 2], including single molecules trapped within porous Zeolite channels [3, 4]. This has been achieved through integrated differential phase contrast STEM mode, known as iDPC-STEM [5–7], which is a dose efficient imaging technique, with directly interpretable contrast transfer function (CTF) and high signal to noise ratio (SNR), as main advantages over the conventional (S)TEM techniques. Recently, biological nano particle structures at near atomic resolution have been also revealed using iDPC-STEM in combination with single particle analysis (SPA) [8, 9]. Previously, SPA has been almost solely used with conventional TEM (CTEM).

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Contributing Institute(s):

1. Strukturbiologie (ER-C-3)

Research Program(s):

1. 5352 - Understanding the Functionality of Soft Matter and Biomolecular Systems (POF4-535) (POF4-535)
2. 5241 - Molecular Information Processing in Cellular Systems (POF4-524) (POF4-524)

Appears in the scientific report 2024

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Database coverage:
; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Current Contents - Physical, Chemical and Earth Sciences ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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