Journal Article

FZJ-2024-03586

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png No evidence for an association of voxel-based morphometry with short-term non-motor outcomes in deep brain stimulation for Parkinson’s disease

Loehrer, P. A. (Corresponding author) ; Schumacher, W. ; Jost, S. T. ; Silverdale, M. ; Petry-Schmelzer, J. N. ; Sauerbier, A. ; Gronostay, A. ; Visser-Vandewalle, V. ; Fink, G. R.FZJ* ; Evans, J. ; Krause, M. ; Rizos, A. ; Antonini, A. ; Ashkan, K. ; Martinez-Martin, P. ; Gaser, C. ; Ray Chaudhuri, K. ; Timmermann, L. ; Baldermann, J. C. ; Dafsari, H. S.

2024
Nature Publ. Group London [u.a.]

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Please use a persistent id in citations: doi:10.1038/s41531-024-00695-1  doi:10.34734/FZJ-2024-03586

Abstract: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established therapy in advanced Parkinson's disease (PD). Motor and non-motor outcomes, however, show considerable inter-individual variability. Preoperative morphometry-based metrics have recently received increasing attention to explain treatment effects. As evidence for the prediction of non-motor outcomes is limited, we sought to investigate the association between metrics of voxel-based morphometry and short-term non-motor outcomes following STN-DBS in this prospective open-label study. Forty-nine PD patients underwent structural MRI and a comprehensive clinical assessment at preoperative baseline and 6-month follow-up. Voxel-based morphometry was used to assess associations between cerebral volume and non-motor outcomes corrected for multiple comparisons using a permutation-based approach. We replicated existing results associating volume loss of the superior frontal cortex with subpar motor outcomes. Overall non-motor burden, however, was not significantly associated with morphometric features, limiting its use as a marker to inform patient selection and holistic preoperative counselling.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)
2. SFB 1451 C07 - Neuronale Grundlagen der Bildung und Unterdrückung motorischer Tics (C07) (458687122) (458687122)
3. DFG project 431549029 - SFB 1451: Schlüsselmechanismen normaler und krankheitsbedingt gestörter motorischer Kontrolle (431549029) (431549029)

Appears in the scientific report 2024

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