Journal Article

FZJ-2025-03147

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Sauerstoffmangel im Gehirn: Perfusion und Verfügbarkeit von A1-Adenosinrezeptoren

Michno, M. (Corresponding author)FZJ* ; Schmitz, J. ; Foerges, A. L.FZJ* ; Beer, S.FZJ* ; Jordan, J. ; Neumaier, B.FZJ* ; Drzezga, A.FZJ* ; Aeschbach, D. ; Bauer, A.FZJ* ; Tank, J. ; Weis, H. ; Elmenhorst, E.-M. ; Elmenhorst, D.FZJ*

2025
Thieme Stuttgart

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Please use a persistent id in citations: doi:10.1055/a-2547-3678  doi:10.34734/FZJ-2025-03147

Abstract: In animal studies, it has been observed that the neuromodula-tor adenosine is released into the interstitial space of the brainduring hypoxia and protects the brain from oxygen deficiencyand overexertion by adjusting cerebral blood flow, metabolismand electrical activity. This study exposed 10 subjects to aninterval of 30-min hypoxia equivalent to the partial pressure ofoxygen at about 5500 m. This resulted in a significant reductionin A 1 adenosine receptor (A 1 AR) availability in the human brain,a significant increase in heart rate, and a significant slowing ofreaction speed. This is to our knowledge the first demonstra-tion in humans that acute hypoxia reduces A 1 AR availability inthe brain. This result supports the hypothesis that hypoxia-in-duced adenosine release leads to increased occupancy of theA 1 AR and can thus pave the way for future countermeasures.

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Contributing Institute(s):

1. Nuklearchemie (INM-5)
2. Molekulare Organisation des Gehirns (INM-2)

Research Program(s):

1. 5253 - Neuroimaging (POF4-525) (POF4-525)

Appears in the scientific report 2025

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Database coverage:
; Clarivate Analytics Master Journal List ; Emerging Sources Citation Index ; IF < 5 ; JCR ; Web of Science Core Collection

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