Journal Article

FZJ-2026-01496

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Compartment-specific correlation of pathological α-synuclein in prodromal Parkinson's disease

Röttgen, S. (First author)FZJ* ; Sommerauer, M. (Corresponding author)FZJ* ; Yan, S. ; Hungerland, C. ; Fink, G. R.FZJ* ; Ophey, A. ; Barbe, M. T. ; Müller, L. ; Tamgüney, G.FZJ* ; Tofaris, G. K.

2026
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.parkreldis.2026.108178  doi:10.34734/FZJ-2026-01496

Abstract: ntroductionNeuronal α-synuclein dyshomeostasis and aggregation are essential features of early Parkinson's disease, as seen in isolated REM sleep behavior disorder (iRBD). The link between these pathologies across body compartments remains unclear. Our aim was to assess correlations between α-synuclein aggregates in stool and urine with α-synuclein content in neuronally derived L1CAM extracellular vesicles (L1EVs) from serum in iRBD.MethodsWe conducted a cross-sectional study, analyzing concurrent biobank samples from 46 individuals with iRBD to quantify α-synuclein aggregates in stool and urine with surface-based fluorescence intensity distribution analysis (sFIDA) and α-synuclein content in L1EVs using electrochemiluminescence.ResultsCorrected for age and sex, α-synuclein concentrations in L1EVs significantly correlated with stool aggregate concentration. No significant correlation was observed between α-synuclein concentration in L1EVs and urine, nor between urine and stool aggregates.ConclusionThe correlation of serum and stool α-synuclein suggests shared or linked pathology across these compartments, whereas the urinary compartment may be pathophysiologically distinct in prodromal Parkinson's Disease.

Note: Funding Else Kroner-Fresenius-Stiftung (grant number 2019_EKES.02); Koln Fortune Program, Faculty of Medicine, University of Cologne; Ilselore-Luckow-Stiftung.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)
2. Strukturbiochemie (IBI-7)

Research Program(s):

1. 5252 - Brain Dysfunction and Plasticity (POF4-525) (POF4-525)

Appears in the scientific report 2026

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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