Journal Article

FZJ-2013-05967

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Rho-kinase: regulation, (dys)function, and inhibition

Amin, E. ; Dubey, B. N. ; Zhang, S.-C. ; Gremer, L.FZJ* ; Dvorsky, R. ; Moll, J. M. ; Taha, M. S. ; Nagel-Steger, L. ; Piekorz, R. P. ; Somlyo, A. V. ; Ahmadian, M. R. (Corresponding author)

2013
de Gruyter Berlin [u.a.]

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Please use a persistent id in citations: http://hdl.handle.net/2128/18352  doi:10.1515/hsz-2013-0181

Abstract: In a variety of normal and pathological cell types, Rho-kinases I and II (ROCKI/II) play a pivotal role in the organization of the nonmuscle and smooth muscle cytoskeleton and adhesion plaques as well as in the regulation of transcription factors. Thus, ROCKI/II activity regulates cellular contraction, motility, morphology, polarity, cell division, and gene expression. Emerging evidence suggests that dysregulation of the Rho-ROCK pathways at different stages is linked to cardiovascular, metabolic, and neurodegenerative diseases as well as cancer. This review focuses on the current status of understanding the multiple functions of Rho-ROCK signaling pathways and various modes of regulation of Rho-ROCK activity, thereby orchestrating a concerted functional response.

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Contributing Institute(s):

1. Strukturbiochemie (ICS-6)

Research Program(s):

1. 452 - Structural Biology (POF2-452) (POF2-452)

Appears in the scientific report 2013

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Database coverage:
; ; Allianz-Lizenz ; BIOSIS Previews ; Current Contents - Life Sciences ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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