Journal Article PreJuSER-21511

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png
Printed Carbon Microelectrodes for Electrochemical Detection of Single Vesicle Release from PC12 Cells

 ;  ;

2012
American Chemical Society Columbus, Ohio

Analytical chemistry 84, 4613 - 4617 () [10.1021/ac300460s]

This record in other databases:    

Please use a persistent id in citations: doi:

Abstract: We present a disposable system for recording neurotransmitter release from individual cells in vitro. A simple yet reliable microelectrode fabrication process is introduced using screen-printed carbon paste. It allows rapid fabrication of devices at low costs without standard clean-room technology. We demonstrate functionality of the system by real-time observation of vesicle release from single PC12 (rat pheochromocytoma) cells. The cells are cultured directly on the chip and can be used for immediate or long-term in vitro experiments. Thus, our approach may serve as a platform for pharmacological cell culture studies.

Keyword(s): Animals (MeSH) ; Carbon: chemistry (MeSH) ; Dopamine: analysis (MeSH) ; Electrochemical Techniques (MeSH) ; Microelectrodes (MeSH) ; Microscopy, Electron, Scanning (MeSH) ; PC12 Cells (MeSH) ; Patch-Clamp Techniques (MeSH) ; Rats (MeSH) ; Secretory Vesicles: metabolism (MeSH) ; Carbon

Classification:

Note: Record converted from VDB: 12.11.2012

Contributing Institute(s):
  1. Bioelektronik (ICS-8)
  2. Bioelektronik (PGI-8)
  3. Jülich-Aachen Research Alliance - Fundamentals of Future Information Technology (JARA-FIT)
Research Program(s):
  1. Grundlagen für zukünftige Informationstechnologien (P42)
  2. BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung (P45)

Appears in the scientific report 2012
Database coverage:
Medline ; Current Contents - Life Sciences ; JCR ; NCBI Molecular Biology Database ; NationallizenzNationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection ; Zoological Record
Click to display QR Code for this record

The record appears in these collections:
Document types > Articles > Journal Article
JARA > JARA > JARA-JARA\-FIT
Institute Collections > IBI > IBI-3
Workflow collections > Public records
ICS > ICS-8
Publications database
PGI-8

 Record created 2012-11-13, last modified 2024-06-19



Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)