Journal Article

PreJuSER-22817

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Nutrient concentration-sensitive microorganism-based biosensor

Werner, C. F.FZJ* ; Gröbel, S. ; Krumbe, C. ; Wagner, T. ; Selmer, T. ; Yoshinobu, T. ; Baumann, M. E. M. ; Keusgen, M. ; Schöning, M. J.FZJ*

2012
Wiley-VCH Weinheim

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Please use a persistent id in citations: doi:10.1002/pssa.201100801

Abstract: This work presents a biosensor based on living cells immobilised on a light-addressable potentiometric sensor (LAPS). The set-up is sensitive to the concentrations of nutrients metabolised by bacteria, which results in an extracellular acidification. This is exemplarily demonstrated with glucose as nutrient and Escherichia coli as microorganism. The function of this biosensor is comparable to an enzyme-based field-effect sensor when using diffusion limitation. With the help of addressability of the LAPS an on-chip differential set-up was developed. Thus, external influences such as sensor drift, temperature and external pH changes can be minimised. (c) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Keyword(s): J ; biosensor (auto) ; extracellular acidification (auto) ; glucose (auto) ; light-addressable potentiometric sensor (auto)

Note: The authors thank the German Federal Ministry of Food, Agriculture and Consumer Protection (BMELV) and the 'Fachagentur Nachwachsende Rohstoffe e. V.' (FNR) for financial support of this work (Bio-LAPS).

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Contributing Institute(s):

1. Bioelektronik (PGI-8)
2. Jülich-Aachen Research Alliance - Fundamentals of Future Information Technology (JARA-FIT)

Research Program(s):

1. Grundlagen für zukünftige Informationstechnologien (P42)

Appears in the scientific report 2012

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Database coverage:
; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection ; Zoological Record

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