| Home > Publications database > Mikrobiologische Einzelzell-Phänotypencharakterisierung im Mikrochip |
| Journal Article | FZJ-2016-01660 |
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2016
Spektrum
Heidelberg
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Please use a persistent id in citations: doi:10.1007/s12268-016-0658-3
Abstract: Microbes adapt to environmental changes by DNA embedded mechanisms (e. g. resistance) or non-DNA based phenotypical differentiation (e. g. tolerance). Single-cell fluorescence imaging combined with environmental control by microfluidic devices helps to unravel phenotypical changes of single microbial cells in isogenic cell populations. Therefore, the intracellular implementation of fluorescent molecules by genetic modification or dynamic staining is essential for non-invasive live-cell imaging.
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