Dissertation / PhD Thesis/Book

PreJuSER-33332

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Parallele Substratkontrolle in Bioreaktoren mit geringem Volumen

Wolfram, E. P. (Corresponding author)FZJ*

2002
Forschungszentrum Jülich GmbH Zenralbibliothek, Verlag Jülich

Please use a persistent id in citations: http://hdl.handle.net/2128/114

Report No.: Juel-3982

Abstract: In the first developmental phase of microbial processes, relevant parameters for reaction engineering are investigated and optimized with parallel experiments in small reactors (shake flask scale) . Substrate concentrations are central process parameters . Their control might help to increase efficiency and quality of this developmental phase . Thus, a parallel, automatic and sterile sampling technique wich hollow fiber membranes was developed that suits the Small reaction volume. The parallel sampling modules were connected to a Substrate analysis system. The combination of the analytical technique with a controller and a precise microdosing System for Substrate closed the control loop. The prototype device was characterized and its suitability for online monitoring and control of bioprocesses confirmed . This technique allows for the firnt time online measurement and control of Substrate concentrations in parallel bioreactions (i.e . with Escherichia coli) wich measuring raten of the order of minutes

Note: Record converted from VDB: 12.11.2012
Note: München, Techn. Univ., Diss., 2001

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Contributing Institute(s):

1. Biotechnologie 2 (IBT-2)

Research Program(s):

1. Verfahrenstechnik zur mikrobiellen Gewinnung von Primärmetaboliten (41.40.0)

Appears in the scientific report 2001

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Database coverage:

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