Journal Article

PreJuSER-6513

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Mirror image phage display - a method to generate D-peptide ligands for use in diagnostic or therapeutical applications?

Funke, S. A.FZJ* ; Willbold, D.FZJ*

2009
Royal Society of Chemistry Cambridge

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Please use a persistent id in citations: doi:10.1039/b904138a

Abstract: Mirror image phage display is a straightforward approach to identify new potentially therapeutically active D-enantiomeric peptides. Such D-peptides are more resistant to proteolytic degradation compared to L-peptides. In this review, several examples of mirror image phage display derived D-peptides with therapeutical potential are introduced and discussed.

Keyword(s): Drug Design (MeSH) ; Ligands (MeSH) ; Peptide Library (MeSH) ; Peptides: chemistry (MeSH) ; Peptides: therapeutic use (MeSH) ; Stereoisomerism (MeSH) ; Ligands ; Peptide Library ; Peptides ; J

Note: This work has been supported by a grant of the Volkswagen-Stiftung to D. W. (I/82 649) and by a grant from the "Prasidentenfond der Helmholtzgemeinschaft'' (HGF, "Virtual Institute of Structural Biology'') to D. W.

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Contributing Institute(s):

1. Strukturbiochemie (ISB-3)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (P33)

Appears in the scientific report 2009

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