Journal Article

FZJ-2016-07767

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Automated synthesis of 4-[$^{18}$F]fluoroanisole, [$^{18}$F]DAA1106 and 4-[$^{18}$F]FPhe using Cu-mediated radiofluorination under “minimalist” conditions

Zischler, J.FZJ* ; Krapf, P.FZJ* ; Richarz, R.FZJ* ; Zlatopolskiy, B. D. ; Neumaier, B. (Corresponding author)FZJ*

2016
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.apradiso.2016.04.030

Abstract: The application of the “minimalist” approach to Cu-mediated radiofluorination allows the efficient preparation of 18F-labeled arenes regardless of their electronic properties. The implementation of this methodology on a commercially available synthesis module (hotboxthree, Scintomics, Germany) enabled the automated production of 4-[18F]fluoroanisole as well as the clinically relevant PET-tracers, 4-[18F]FPhe and [18F]DAA1106, in radiochemical yields of 41–61% and radiochemical purities of >95% within 30–60 min. These results demonstrated the high efficacy and versatility of the developed method that will open up opportunities for a broad application of Cu-mediated radiofluorination in PET-chemistry.

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Contributing Institute(s):

1. Nuklearchemie (INM-5)

Research Program(s):

1. 573 - Neuroimaging (POF3-573) (POF3-573)

Appears in the scientific report 2016

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Database coverage:
; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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