Journal Article

FZJ-2017-04104

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Graphene Multielectrode Arrays as a Versatile Tool for Extracellular Measurements552

Kireev, D.FZJ* ; Seyock, S. ; Lewen, J.FZJ* ; Maybeck, V. ; Wolfrum, B.FZJ* ; Offenhäusser, A. (Corresponding author)FZJ*

2017
Wiley-VCH Weinheim

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Please use a persistent id in citations: http://hdl.handle.net/2128/15738  doi:10.1002/adhm.201601433

Abstract: Graphene multielectrode arrays (GMEAs) presented in this work are used for cardio and neuronal extracellular recordings. The advantages of the graphene as a part of the multielectrode arrays are numerous: from a general flexibility and biocompatibility to the unique electronic properties of graphene. The devices used for extensive in vitro studies of a cardiac-like cell line and cortical neuronal networks show excellent ability to extracellularly detect action potentials with signal to noise ratios in the range of 45 ± 22 for HL-1 cells and 48 ± 26 for spontaneous bursting/spiking neuronal activity. Complex neuronal bursting activity patterns as well as a variety of characteristic shapes of HL-1 action potentials are recorded with the GMEAs. This paper illustrates that the potential applications of the GMEAs in biological and medical research are still numerous and diverse.

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Contributing Institute(s):

1. Bioelektronik (ICS-8)

Research Program(s):

1. 552 - Engineering Cell Function (POF3-552) (POF3-552)

Appears in the scientific report 2017

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Database coverage:
; ; BIOSIS Previews ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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