Journal Article

FZJ-2017-06125

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The Atg8 Family of Proteins—Modulating Shape and Functionality of Autophagic Membranes

Abdollahzadeh, I.FZJ* ; Schwarten, M.FZJ* ; Gensch, T.FZJ* ; Willbold, D. (Corresponding author)FZJ* ; Weiergräber, O. H. (Corresponding author)FZJ*

2017
Frontiers Media Lausanne

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Please use a persistent id in citations: http://hdl.handle.net/2128/15199  doi:10.3389/fgene.2017.00109

Abstract: Aging is a multifactorial process involving an accumulation of alterations on various organizational levels, which finally compromises viability and limits the lifespan of organisms. It is now well-established that many aspects of aging can be positively affected by (macro)autophagy, a mechanism of self-digestion found in virtually all eukaryotic cells. A comprehensive understanding of autophagy is thus expected to not only deepen our insight into the mechanisms of aging but to also open up new avenues toward increasing the healthy lifespan in humans. In this review, we focus on the Atg8 family of ubiquitin-like proteins, which play a crucial role in the autophagy process by virtue of their unique mode of reversible membrane association.

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Contributing Institute(s):

1. Strukturbiochemie (ICS-6)
2. Zelluläre Biophysik (ICS-4)

Research Program(s):

1. 552 - Engineering Cell Function (POF3-552) (POF3-552)

Appears in the scientific report 2017

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Database coverage:
; ; ; ; BIOSIS Previews ; DOAJ Seal ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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