Journal Article

FZJ-2017-08380

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity

Ortega, J. A. ; Riccardi, L. ; Minniti, E. ; Borgogno, M. ; Arencibia, J. M. ; Greco, M. L. ; Minarini, A. ; Sissi, C. (Corresponding author) ; De Vivo, M. (Corresponding author)FZJ*

2018
ACS Washington, DC

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Please use a persistent id in citations: http://hdl.handle.net/2128/17604  doi:10.1021/acs.jmedchem.7b01388

Abstract: We used a pharmacophore hybridization strategy to combine key structural elements of merbarone and etoposide and generated new type II topoisomerase (topoII) poisons. This first set of hybrid topoII poisons shows promising antiproliferative activity on human cancer cells, endorsing their further exploration for anticancer drug discovery.

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Contributing Institute(s):

1. Computational Biomedicine (IAS-5)
2. Computational Biomedicine (INM-9)

Research Program(s):

1. 574 - Theory, modelling and simulation (POF3-574) (POF3-574)

Appears in the scientific report 2018

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Database coverage:
; ; BIOSIS Previews ; Current Contents - Life Sciences ; Ebsco Academic Search ; Free to read ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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