Journal Article

FZJ-2018-01583

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Recognition motif and mechanism of ripening inhibitory peptides in plant hormone receptor ETR1

Milić, D. ; Dick, M. ; Mulnaes, D. ; Pfleger, C. ; Kinnen, A. ; Gohlke, H. (Corresponding author)FZJ* ; Groth, G. (Corresponding author)

2018
Nature Publishing Group London

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Please use a persistent id in citations: http://hdl.handle.net/2128/17555  doi:10.1038/s41598-018-21952-3

Abstract: Synthetic peptides derived from ethylene-insensitive protein 2 (EIN2), a central regulator of ethylene signalling, were recently shown to delay fruit ripening by interrupting protein–protein interactions in the ethylene signalling pathway. Here, we show that the inhibitory peptide NOP-1 binds to the GAF domain of ETR1 – the prototype of the plant ethylene receptor family. Site-directed mutagenesis and computational studies reveal the peptide interaction site and a plausible molecular mechanism for the ripening inhibition.

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Contributing Institute(s):

1. Jülich Supercomputing Center (JSC)
2. John von Neumann - Institut für Computing (NIC)
3. Strukturbiochemie (ICS-6)

Research Program(s):

1. 511 - Computational Science and Mathematical Methods (POF3-511) (POF3-511)
2. 574 - Theory, modelling and simulation (POF3-574) (POF3-574)
3. 582 - Plant Science (POF3-582) (POF3-582)
4. BioSC - Bioeconomy Science Center (BioSC) (BioSC)
5. Forschergruppe Gohlke (hkf7_20170501) (hkf7_20170501)

Appears in the scientific report 2018

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