Journal Article

FZJ-2018-02171

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Neocortical electrical stimulation for epilepsy: Closed-loop versus open-loop

Vassileva, A.FZJ* ; van Blooijs, D. (Corresponding author) ; Leijten, F. ; Huiskamp, G.

2018
Elsevier89326 Amsterdam [u.a.]

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Please use a persistent id in citations: http://hdl.handle.net/2128/21401  doi:10.1016/j.eplepsyres.2018.02.010

Abstract: The aim of this review is to evaluate whether open-loop or closed-loop neocortical electrical stimulation should be the preferred approach to manage seizures in intractable epilepsy.Twenty cases of open-loop neocortical stimulation with an implanted device have been reported, in 5 case studies. Closed-loop stimulation with an implanted device has been investigated in a larger number of patients in the RNS System clinical trials. With 230 patients enrolled at the start of the Long-term Treatment Trial, 115 remained at the last reported follow-up. Open-loop stimulation reduced seizure frequency in patients on average with over 90% compared to baseline. Closed-loop stimulation reduces seizure frequency with 60%–65%.Even though open-loop neocortical electrical stimulation has only been reported in 20 patients, and closed-loop in much a larger sample, evidence suggests that both approaches are effective in reducing seizures. It remains an open question which should be clinically preferred. Therefore, a head-to-head adaptive clinical study comparing both approaches is proposed

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)
2. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 572 - (Dys-)function and Plasticity (POF3-572) (POF3-572)

Appears in the scientific report 2018

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Database coverage:
; ; BIOSIS Previews ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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