Journal Article FZJ-2019-03789

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Minimalist approach meets green chemistry: Synthesis of 18F-labeled (hetero)aromatics in pure ethanol

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2019
Wiley New York, NY [u.a.]

Journal of labelled compounds and radiopharmaceuticals 62(8), 404 - 410 () [10.1002/jlcr.3776]

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Abstract: The application of toxic solvents and additives is inevitable for most of the described protocols for 18F‐labeling. Herein, a novel “green” procedure for nucleophilic aromatic radiofluorination of highly activated (hetero)aromatic substrates in pure EtOH is described. Using this method a series of 18F‐labeled (hetero)arenes have been synthesized in radiochemical yields (RCYs) of up to 97%.

Classification:

Contributing Institute(s):
  1. Nuklearchemie (INM-5)
Research Program(s):
  1. 573 - Neuroimaging (POF3-573) (POF3-573)

Appears in the scientific report 2019
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 Record created 2019-07-12, last modified 2021-01-30


Published on 2019-06-04. Available in OpenAccess from 2020-06-04.:
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