Home > Publications database > Minimalist approach meets green chemistry: Synthesis of 18F-labeled (hetero)aromatics in pure ethanol |
Journal Article | FZJ-2019-03789 |
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2019
Wiley
New York, NY [u.a.]
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Please use a persistent id in citations: http://hdl.handle.net/2128/22487 doi:10.1002/jlcr.3776
Abstract: The application of toxic solvents and additives is inevitable for most of the described protocols for 18F‐labeling. Herein, a novel “green” procedure for nucleophilic aromatic radiofluorination of highly activated (hetero)aromatic substrates in pure EtOH is described. Using this method a series of 18F‐labeled (hetero)arenes have been synthesized in radiochemical yields (RCYs) of up to 97%.
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