Journal Article

FZJ-2020-00789

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The effects of thalamic and posterior subthalamic deep brain stimulation on speech in patients with essential tremor – A prospective, randomized, doubleblind crossover study

Becker, J. ; Thies, T. ; Petry-Schmelzer, J. N. ; Dembek, T. A. ; Reker, P. ; Mücke, D. ; Grice, M. ; Visser-Vandewalle, V. ; Fink, G. R.FZJ* ; Barbe, M. (Corresponding author)

2020
Elsevier Amsterdam [u.a.]

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Please use a persistent id in citations: http://hdl.handle.net/2128/24152  doi:10.1016/j.bandl.2019.104724

Abstract: ObjectiveTo prospectively evaluate the effect of PSA- and VIM DBS on speech in ET patients.MethodsLeads were implanted bilaterally with contacts placed in both VIM and PSA. Thirteen patients were analyzed pre- and postoperatively. Preoperative speech of ET patients was compared to healthy controls. PSA- and VIM-DBS were evaluated in a randomized, double-blind crossover phase.ResultsAt preoperative baseline, we found reduced intelligibility. Differences in acoustic and VAS data (‘ability to speak’) compared to controls were gradient. Articulation rate could be predicted by disease duration. Decreased articulation rate, spirantization and voicing were found for PSA- and VIM-DBS. Targets did not differ in terms of speech deterioration.ConclusionSpeech in ET patients without DBS can be impaired, dependent on patient’s individual characteristics. Both PSA- and VIM-DBS affect speech in a comparable way. Thus, the PSA can be considered an alternative DBS target in ET without higher risk of dysarthria.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 572 - (Dys-)function and Plasticity (POF3-572) (POF3-572)

Appears in the scientific report 2020

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Database coverage:
; ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Current Contents - Social and Behavioral Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Social Sciences Citation Index ; Web of Science Core Collection

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