Journal Article

FZJ-2020-01573

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The interrelation of sleep and mental and physical health is anchored in grey-matter neuroanatomy and under genetic control

Tahmasian, M. ; Samea, F. ; Khazaie, H. ; Zarei, M. ; Kharabian Masouleh, S.FZJ* ; Hoffstaedter, F.FZJ* ; Camilleri, J.FZJ* ; Kochunov, P. ; Yeo, B. T. T. ; Eickhoff, S. B.FZJ* ; Valk, S. L. (Corresponding author)FZJ*

2020
Springer Nature London

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Please use a persistent id in citations: http://hdl.handle.net/2128/24680  doi:10.1038/s42003-020-0892-6

Abstract: Humans need about seven to nine hours of sleep per night. Sleep habits are heritable, associated with brain function and structure, and intrinsically related to well-being, mental, and physical health. However, the biological basis of the interplay of sleep and health is incompletely understood. Here we show, by combining neuroimaging and behavioral genetic approaches in two independent large-scale datasets (HCP (n = 1106), age range: 22–37, eNKI (n = 783), age range: 12–85), that sleep, mental, and physical health have a shared neurobiological basis in grey matter anatomy; and that these relationships are driven by shared genetic factors. Though local associations between sleep and cortical thickness were inconsistent across samples, we identified two robust latent components, highlighting the multivariate interdigitation of sleep, intelligence, BMI, depression, and macroscale cortical structure. Our observations provide a system-level perspective on the interrelation of sleep, mental, and physical conditions, anchored in grey-matter neuroanatomy.

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Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 572 - (Dys-)function and Plasticity (POF3-572) (POF3-572)

Appears in the scientific report 2020

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Database coverage:
; ; ; DOAJ Seal

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