Journal Article

FZJ-2020-03031

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Benzoate Synthesis from Glucose or Glycerol Using Engineered Pseudomonas taiwanensis

Otto, M.FZJ* ; Wynands, B.FZJ* ; Marienhagen, J.FZJ* ; Blank, L. M.Extern* ; Wierckx, N. (Corresponding author)FZJ*

2020
Wiley-VCH Weinheim

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Please use a persistent id in citations: http://hdl.handle.net/2128/26281  doi:10.1002/biot.202000211

Abstract: Benzoic acid is one of the most commonly used food preservatives, but currently exclusively produced in petrochemical processes. In this study, a bio‐based production pathway using an engineered strain of Pseudomonas taiwanensis is described. In a phenylalanine‐overproducing strain, bacterial and plant genes are heterologously expressed to achieve production of benzoate via a β‐oxidation pathway. Strategic disruption of the native Pseudomonas benzoate degradation pathway further allows the production of catechol and cis,cis‐muconate. Taken together, this work demonstrates new routes for the microbial production of these industrially relevant chemicals from renewable resources.

Note: weitere Grants: German Research Foundation (DFG) through the Emmy Noether program (WI 4255/1‐1) German Federal Ministry of Education and Research (BMBF) through the NO‐STRESS project (FKZ 031B0852A)

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Contributing Institute(s):

1. Biotechnologie (IBG-1)

Research Program(s):

1. 581 - Biotechnology (POF3-581) (POF3-581)
2. DFG project 390919832 - EXC 2186: Das Fuel Science Center – Adaptive Umwandlungssysteme für erneuerbare Energie- und Kohlenstoffquellen (390919832) (390919832)

Appears in the scientific report 2020

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; DEAL Wiley ; Essential Science Indicators ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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