Journal Article

FZJ-2021-00815

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Simultaneous BOLD-fMRI and constant infusion FDG-PET data of the resting human brain

Jamadar, S. D. (Corresponding author) ; Ward, P. G. D. ; Close, T. G. ; Fornito, A. ; Premaratne, M. ; O’Brien, K. ; Stäb, D. ; Chen, Z. ; Shah, N. J.FZJ* ; Egan, G. F.

2020
Nature Publ. Group London

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Please use a persistent id in citations: http://hdl.handle.net/2128/27047  doi:10.1038/s41597-020-00699-5

Abstract: Simultaneous [18 F]-fluorodeoxyglucose positron emission tomography and functional magnetic resonance imaging (FDG-PET/fMRI) provides the capability to image two sources of energetic dynamics in the brain – cerebral glucose uptake and the cerebrovascular haemodynamic response. Resting-state fMRI connectivity has been enormously useful for characterising interactions between distributed brain regions in humans. Metabolic connectivity has recently emerged as a complementary measure to investigate brain network dynamics. Functional PET (fPET) is a new approach for measuring FDG uptake with high temporal resolution and has recently shown promise for assessing the dynamics of neural metabolism. Simultaneous fMRI/fPET is a relatively new hybrid imaging modality, with only a few biomedical imaging research facilities able to acquire FDG PET and BOLD fMRI data simultaneously. We present data for n = 27 healthy young adults (18–20 yrs) who underwent a 95-min simultaneous fMRI/fPET scan while resting with their eyes open. This dataset provides significant re-use value to understand the neural dynamics of glucose metabolism and the haemodynamic response, the synchrony, and interaction between these measures, and the development of new single- and multi-modality image preparation and analysis procedures.

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Contributing Institute(s):

1. Physik der Medizinischen Bildgebung (INM-4)
2. Jara-Institut Quantum Information (INM-11)
3. Jülich-Aachen Research Alliance - Translational Brain Medicine (JARA-BRAIN)

Research Program(s):

1. 573 - Neuroimaging (POF3-573) (POF3-573)

Appears in the scientific report 2020

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