Journal Article

FZJ-2021-01899

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A multimodal meta-analysis of regional structural and functional brain alterations in type 2 diabetes

Yao, L. ; Yang, C. ; Zhang, W. ; Li, S. ; Li, Q. ; Chen, L. ; Lui, S. ; Kemp, G. J. ; Biswal, B. B. ; Shah, N. J.FZJ* ; Li, F. ; Gong, Q. (Corresponding author)

2021
Academic Press Orlando, Fla.

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Please use a persistent id in citations: http://hdl.handle.net/2128/27688  doi:10.1016/j.yfrne.2021.100915

Abstract: Neuroimaging studies have identified brain structural and functional alterations of type 2 diabetes mellitus (T2DM) patients; however, there is no systematic information on the relations between abnormalities in these two domains. We conducted a multimodal meta-analysis of voxel-based morphometry and regional resting-state functional MRI studies in T2DM, including fifteen structural datasets (693 patients and 684 controls) and sixteen functional datasets (378 patients and 358 controls). We found, in patients with T2DM compared to controls, conjoint decreased regional gray matter volume (GMV) and altered intrinsic activity mainly in the default mode network including bilateral superior temporal gyrus/Rolandic operculum, left middle and inferior temporal gyrus, and left supramarginal gyrus; decreased GMV alone in the limbic system; and functional abnormalities alone in the cerebellum, insula, and visual cortex. This meta-analysis identified complicated patterns of conjoint and dissociated brain alterations in T2DM patients, which may help provide new insight into the neuropathology of T2DM.

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Contributing Institute(s):

1. Physik der Medizinischen Bildgebung (INM-4)

Research Program(s):

1. 525 - Decoding Brain Organization and Dysfunction (POF4-525) (POF4-525)

Appears in the scientific report 2021

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