Journal Article

FZJ-2021-02159

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Implementation of an Enclosed Ionization Interface for the Analysis of Liquid Sample Streams with Direct Analysis in Real Time Mass Spectrometry

Kloth, R. (Corresponding author)FZJ* ; Khanipour, P.FZJ* ; Mayrhofer, K. J. J.FZJ* ; Katsounaros, I.FZJ*

2021
Wiley Interscience New York, NY

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Please use a persistent id in citations: http://hdl.handle.net/2128/27892  doi:10.1002/rcm.9091

Abstract: Rationale: The development of an interface to introduce liquid sample streams to directanalysis in real time mass spectrometry (DART-MS) is of great interest for coupling variousanalytical techniques, using non-volatile salts, with MS. Therefore, we devised an enclosedionization interface and a sample introduction system for the versatile analysis of liquidsamples with DART-MS.Methods: The sample introduction system consists of a nebulizer, a spray chamber and atransfer line, while the confined ionization interface is created by implementing a cross-shapedhousing between the ion source and the MS inlet. Methodical studies of the effects of varioussetup parameters on signal intensity and peak shape were conducted, while its diverseapplicability was demonstrated by coupling with high-performance liquid chromatography(HPLC) for the analysis of alcohols, organic acids and furanic compounds.Results: The confinement of the ionization interface results in a robust setup design with awell-defined ionization region for focusing of the sprayed sample mist. Thereby, an increasein analyte signal intensity by three orders of magnitude and improved signal stability andreproducibility were obtained in comparison to a similar open ionization interfaceconfiguration. Additionally, the successful quantification of alcohols could be demonstrated aswell as the compatibility of the setup with HPLC gradient elution.Conclusions: A versatile setup design for the analysis of liquid sample streams with DARTMSwas devised for monitoring reactions or hyphenating analytics with MS. It minimizesThis article is protected by copyright. All rights reserved.interferences from the laboratory surrounding as well as allows for safe handling of hazardousand toxic chemicals, which renders it suitable for a broad range of applications.

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Contributing Institute(s):

1. Helmholtz-Institut Erlangen-Nürnberg Erneuerbare Energien (IEK-11)

Research Program(s):

1. 123 - Chemische Energieträger (POF4-123) (POF4-123)

Appears in the scientific report 2021

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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