Journal Article

FZJ-2021-03075

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Skin under Strain: From Epithelial Model Tissues to Adult Epithelia

Püllen, R.FZJ* ; Konrad, J.FZJ* ; Merkel, R.FZJ* ; Hoffmann, B. (Corresponding author)FZJ*

2021
MDPI Basel

This record in other databases:      

Please use a persistent id in citations: http://hdl.handle.net/2128/28346  doi:10.3390/cells10071834

Abstract: Formation of a barrier capable of protecting tissue from external damage, chemical factors, and pathogens is one of the main functions of the epidermis. Furthermore, upon development and during aging, mechanoprotective epidermal functions change dramatically. However, comparative studies between embryonic and adult skin in comparison to skin equivalents are still scarce which is especially due to the lack of appropriate measurement systems with sufficient accuracy and long-term tissue compatibility. Our studies fill this gap by developing a combined bioreactor and tensile testing machine for biomechanical analysis of living epithelia. Based on this tissue stretcher, our data clearly show that viscoelastic and plastic deformation behavior of embryonic and adult skin differ significantly. Tissue responses to static strain compared to cyclic strain also show a clear dependence on differentiation stage. Multilayered unkeratinized epidermis equivalents, on the other hand, respond very similar to mechanical stretch as adult tissue. This mechanical similarity is even more evident after a single cycle of mechanical preconditioning. Our studies therefore suggest that skin equivalents are well suited model systems to analyze cellular interactions of epidermal cells in natural tissues

---

Contributing Institute(s):

1. Mechanobiologie (IBI-2)

Research Program(s):

1. 5243 - Information Processing in Distributed Systems (POF4-524) (POF4-524)
2. DFG project 273723265 - Mechanosensation und Mechanoreaktion in epidermalen Systemen (273723265)

Appears in the scientific report 2021

---

Database coverage:
; ; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; IF < 5 ; JCR ; PubMed Central ; Science Citation Index Expanded ; Web of Science Core Collection

---