Journal Article

FZJ-2021-04331

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Analysis of structural brain asymmetries in attention‐deficit/hyperactivity disorder in 39 datasets

Postema, M. C. ; Hoogman, M. ; Ambrosino, S. ; Asherson, P. ; Banaschewski, T. ; Bandeira, C. E. ; Baranov, A. ; Bau, C. H. D. ; Baumeister, S. ; Baur-Streubel, R. ; Bellgrove, M. A. ; Biederman, J. ; Bralten, J. ; Brandeis, D. ; Brem, S. ; Buitelaar, J. K. ; Busatto, G. F. ; Castellanos, F. X. ; Cercignani, M. ; Chaim-Avancini, T. M. ; Chantiluke, K. C. ; Christakou, A. ; Coghill, D. ; Conzelmann, A. ; Cubillo, A. I. ; Cupertino, R. B. ; Zeeuw, P. ; Doyle, A. E. ; Durston, S. ; Earl, E. A. ; Epstein, J. N. ; Ethofer, T. ; Fair, D. A. ; Fallgatter, A. J. ; Faraone, S. V. ; Frodl, T. ; Gabel, M. C. ; Gogberashvili, T. ; Grevet, E. H. ; Haavik, J. ; Harrison, N. A. ; Hartman, C. A. ; Heslenfeld, D. J. ; Hoekstra, P. J. ; Hohmann, S. ; Høvik, M. F. ; Jernigan, T. L. ; Kardatzki, B. ; Karkashadze, G. ; Kelly, C. ; Kohls, G. ; Konrad, K.FZJ* ; Kuntsi, J. ; Lazaro, L. ; Lera-Miguel, S. ; Lesch, K.-P. ; Louza, M. R. ; Lundervold, A. J. ; Malpas, C. B. ; Mattos, P. ; McCarthy, H. ; Namazova-Baranova, L. ; Nicolau, R. ; Nigg, J. T. ; Novotny, S. E. ; Oberwelland Weiss, E.FZJ* ; O'Gorman Tuura, R. L. ; Oosterlaan, J. ; Oranje, B. ; Paloyelis, Y. ; Pauli, P. ; Picon, F. A. ; Plessen, K. J. ; Ramos-Quiroga, J. A. ; Reif, A. ; Reneman, L. ; Rosa, P. G. P. ; Rubia, K. ; Schrantee, A. ; Schweren, L. J. S. ; Seitz, J. ; Shaw, P. ; Silk, T. J. ; Skokauskas, N. ; Soliva Vila, J. C. ; Stevens, M. C. ; Sudre, G. ; Tamm, L. ; Tovar-Moll, F. ; Erp, T. G. M. ; Vance, A. ; Vilarroya, O. ; Vives-Gilabert, Y. ; Polier, G. G. ; Walitza, S. ; Yoncheva, Y. N. ; Zanetti, M. V. ; Ziegler, G. C. ; Glahn, D. C. ; Jahanshad, N. ; Medland, S. E. ; Thompson, P. M. ; Fisher, S. E. ; Franke, B. ; Francks, C. (Corresponding author)

2021
Wiley-Blackwell Oxford

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Please use a persistent id in citations: http://hdl.handle.net/2128/29037  doi:10.1111/jcpp.13396

Abstract: ObjectiveSome studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left-right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium.MethodsWe analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 unaffected controls. Asymmetry Indexes (AIs) were calculated per participant for each bilaterally paired measure, and linear mixed effects modeling was applied separately in children, adolescents, adults, and the total sample, to test exhaustively for potential associations of ADHD with structural brain asymmetries.ResultsThere was no evidence for altered caudate nucleus asymmetry in ADHD, in contrast to prior literature. In children, there was less rightward asymmetry of the total hemispheric surface area compared to controls (t = 2.1, p = .04). Lower rightward asymmetry of medial orbitofrontal cortex surface area in ADHD (t = 2.7, p = .01) was similar to a recent finding for autism spectrum disorder. There were also some differences in cortical thickness asymmetry across age groups. In adults with ADHD, globus pallidus asymmetry was altered compared to those without ADHD. However, all effects were small (Cohen’s d from −0.18 to 0.18) and would not survive study-wide correction for multiple testing.ConclusionPrior studies of altered structural brain asymmetry in ADHD were likely underpowered to detect the small effects reported here. Altered structural asymmetry is unlikely to provide a useful biomarker for ADHD, but may provide neurobiological insights into the trait.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)

Appears in the scientific report 2021

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; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Social and Behavioral Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Social Sciences Citation Index ; Web of Science Core Collection

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