Journal Article

FZJ-2021-05917

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Inkjet-Printed and Electroplated 3D Electrodes for Recording Extracellular Signals in Cell Culture

Grob, L.Extern* ; Rinklin, P.FZJ* ; Zips, S. ; Mayer, D.FZJ* ; Weidlich, S.FZJ* ; Terkan, K. ; Weiß, L. J. K.Extern* ; Adly, N.FZJ* ; Offenhäusser, A.FZJ* ; Wolfrum, B. (Corresponding author)FZJ*

2021
MDPI Basel

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Please use a persistent id in citations: http://hdl.handle.net/2128/33193  doi:10.3390/s21123981

Abstract: Recent investigations into cardiac or nervous tissues call for systems that are able to electrically record in 3D as opposed to 2D. Typically, challenging microfabrication steps are required to produce 3D microelectrode arrays capable of recording at the desired position within the tissue of interest. As an alternative, additive manufacturing is becoming a versatile platform for rapidly prototyping novel sensors with flexible geometric design. In this work, 3D MEAs for cell-culture applications were fabricated using a piezoelectric inkjet printer. The aspect ratio and height of the printed 3D electrodes were user-defined by adjusting the number of deposited droplets of silver nanoparticle ink along with a continuous printing method and an appropriate drop-to-drop delay. The Ag 3D MEAs were later electroplated with Au and Pt in order to reduce leakage of potentially cytotoxic silver ions into the cellular medium. The functionality of the array was confirmed using impedance spectroscopy, cyclic voltammetry, and recordings of extracellular potentials from cardiomyocyte-like HL-1 cell

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Contributing Institute(s):

1. Bioelektronik (IBI-3)

Research Program(s):

1. 5244 - Information Processing in Neuronal Networks (POF4-524) (POF4-524)

Appears in the scientific report 2022

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Database coverage:
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