Journal Article

FZJ-2021-06060

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Mutasynthesis of Physostigmines in Myxococcus xanthus

Winand, L. ; Schneider, P.FZJ* ; Kruth, S. ; Greven, N.-J. ; Hiller, W. ; Kaiser, M. ; Pietruszka, J.FZJ* ; Nett, M. (Corresponding author)

2021
ACS Washington, DC

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Please use a persistent id in citations: doi:10.1021/acs.orglett.1c02374

Abstract: The alkaloid physostigmine is an approved anticholinergic drug and an important lead structure for the development of novel therapeutics. Using a complementary approach that merged chemical synthesis with pathway refactoring, we produced a series of physostigmine analogues with altered specificity and toxicity profiles in the heterologous host Myxococcus xanthus. The compounds that were generated by applying a simple feeding strategy include the promising drug candidate phenserine, which was previously accessible only by total synthesis.

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Contributing Institute(s):

1. Biotechnologie (IBG-1)
2. Institut für Bioorganische Chemie (HHUD) (IBOC)

Research Program(s):

1. 2171 - Biological and environmental resources for sustainable use (POF4-217) (POF4-217)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Chemical Reactions ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; Index Chemicus ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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