Journal Article

FZJ-2022-03306

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Terminal H-reflex Measurements in Mice

Wieters, F. ; Gruhn, M. ; Büschges, A. ; Fink, G. R.FZJ* ; Aswendt, M. (Corresponding author)

2022
JoVE Cambridge, MA

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Please use a persistent id in citations: http://hdl.handle.net/2128/33057  doi:10.3791/63304

Abstract: The Hoffmann reflex (H-reflex), as an electrical analog to the stretch reflex, allowselectrophysiological validation of the integrity of neural circuits after injuries such asspinal cord damage or stroke. An increase of the H-reflex response, together withsymptoms like non-voluntary muscle contractions, pathologically augmented stretchreflex, and hypertonia in the corresponding muscle, is an indicator of post-strokespasticity (PSS).In contrast to rather nerve-unspecific transcutaneous measurements, here, we presenta protocol to quantify the H-reflex directly at the ulnar and median nerves of theforepaw, which is applicable, with minor modifications, to the tibial and sciatic nerveof the hindpaw. Based on the direct stimulation and the adaptation to different nerves,the method represents a reliable and versatile tool to validate electrophysiologicalchanges in spasticity-related disease models.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)

Appears in the scientific report 2022

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Database coverage:
; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Essential Science Indicators ; IF < 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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