Journal Article

FZJ-2022-03615

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Antiphage small molecules produced by bacteria – beyond protein-mediated defenses

Hardy, A.FZJ* ; Kever, L.FZJ* ; Frunzke, J. (Corresponding author)FZJ*

2023
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: http://hdl.handle.net/2128/33329  doi:10.1016/j.tim.2022.08.001

Abstract: Bacterial populations face the constant threat of viral predation exerted by bacteriophages (‘phages’). In response, bacteria have evolved a wide range of defense mechanisms against phage challenges. Yet the vast majority of antiphage defense systems described until now are mediated by proteins or RNA complexes acting at the single-cell level. Here, we review small molecule-based defense strategies against phage infection, with a focus on the antiphage molecules described recently. Importantly, inhibition of phage infection by excreted small molecules has the potential to protect entire bacterial communities, highlighting the ecological significance of these antiphage strategies. Considering the immense repertoire of bacterial metabolites, we envision that the list of antiphage small molecules will be further expanded in the future.

Note: Biotechnologie 1

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Contributing Institute(s):

1. Biotechnologie (IBG-1)

Research Program(s):

1. 2171 - Biological and environmental resources for sustainable use (POF4-217) (POF4-217)
2. DFG project 464434020 - Inhibierung der Phageninfektion durch aktinobakterielle Sekundärmetabolite (464434020) (464434020)

Appears in the scientific report 2022

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Database coverage:
; ; ; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 15 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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