Journal Article

FZJ-2022-05395

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity.

Maity, D. ; Oh, Y. ; Gremer, L.FZJ* ; Hoyer, W. (Corresponding author)FZJ* ; Magzoub, M. ; Hamilton, A. D.

2022
Wiley-VCH Weinheim

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Please use a persistent id in citations: http://hdl.handle.net/2128/32919  doi:10.1002/chem.202201698

Abstract: Invited for the cover of this issue is the group of Prof. Hamilton at New York University. The image depicts how cucurbit[7]uril inhibits islet amyloid polypeptide self-assembly that rescues rat insulinoma cells (a pancreatic β-cell model) from assembly-associated cytotoxicity. Read the full text of the article at 10.1002/chem.202200456.

Keyword(s): Amyloid (MeSH) ; Animals (MeSH) ; Bridged-Ring Compounds: pharmacology (MeSH) ; Heterocyclic Compounds, 2-Ring (MeSH) ; Humans (MeSH) ; Imidazoles: pharmacology (MeSH) ; Imidazolidines (MeSH) ; Insulin-Secreting Cells (MeSH) ; Islet Amyloid Polypeptide (MeSH) ; Macrocyclic Compounds (MeSH) ; Rats (MeSH) ; Amyloid ; Bridged-Ring Compounds ; Heterocyclic Compounds, 2-Ring ; Imidazoles ; Imidazolidines ; Islet Amyloid Polypeptide ; Macrocyclic Compounds ; cucurbit(7)uril

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Contributing Institute(s):

1. Strukturbiochemie (IBI-7)

Research Program(s):

1. 5244 - Information Processing in Neuronal Networks (POF4-524) (POF4-524)

Appears in the scientific report 2022

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Database coverage:
; ; Chemical Reactions ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; Index Chemicus ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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