Journal Article

FZJ-2024-05605

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A Layered Microcircuit Model of Somatosensory Cortex with Three Interneuron Types and Cell-Type-Specific Short-Term Plasticity

Jiang, H.-J. (Corresponding author)FZJ* ; Qi, G.FZJ* ; Duarte, R. ; Feldmeyer, D.FZJ* ; van Albada, S. (Corresponding author)FZJ*

2024
Oxford Univ. Press Oxford

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Please use a persistent id in citations: doi:10.1093/cercor/bhae378  doi:10.34734/FZJ-2024-05605

Abstract: Three major types of GABAergic interneurons, parvalbumin-, somatostatin-, and vasoactive intestinal peptide-expressing (PV, SOM, VIP) cells, play critical but distinct roles in the cortical microcircuitry. Their specific electrophysiology and connectivity shape their inhibitory functions. To study the network dynamics and signal processing specific to these cell types in the cerebral cortex, we developed a multi-layer model incorporating biologically realistic interneuron parameters from rodent somatosensory cortex. The model is fitted to in vivo data on cell-type-specific population firing rates. With a protocol of cell-type-specific stimulation, network responses when activating different neuron types are examined. The model reproduces the experimentally observed inhibitory effects of PV and SOM cells and disinhibitory effect of VIP cells on excitatory cells. We further create a version of the model incorporating cell-type-specific short-term synaptic plasticity (STP). While the ongoing activity with and without STP is similar, STP modulates the responses of Exc, SOM, and VIP cells to cell-type-specific stimulation, presumably by changing the dominant inhibitory pathways. With slight adjustments, the model also reproduces sensory responses of specific interneuron types recorded in vivo. Our model provides predictions on network dynamics involving cell-type-specific short-term plasticity and can serve to explore the computational roles of inhibitory interneurons in sensory functions.

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Contributing Institute(s):

1. Computational and Systems Neuroscience (IAS-6)
2. Jara-Institut Brain structure-function relationships (INM-10)

Research Program(s):

1. 5231 - Neuroscientific Foundations (POF4-523) (POF4-523)
2. HBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539) (945539)
3. EBRAINS 2.0 - EBRAINS 2.0: A Research Infrastructure to Advance Neuroscience and Brain Health (101147319) (101147319)
4. DFG project G:(GEPRIS)491111487 - Open-Access-Publikationskosten / 2022 - 2024 / Forschungszentrum Jülich (OAPKFZJ) (491111487) (491111487)

Appears in the scientific report 2024

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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