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| Hauptseite > Publikationsdatenbank > A magnetic resonance spectroscopy approach to quantitatively measure GABA and phosphorus level changes in the primary motor cortex elicited by transcranial direct current stimulation |
| Hauptseite > Publikationsdatenbank > A magnetic resonance spectroscopy approach to quantitatively measure GABA and phosphorus level changes in the primary motor cortex elicited by transcranial direct current stimulation |
| Contribution to a book | FZJ-2025-01232 |
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2024
De Gruyter
Berlin/ Boston
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Please use a persistent id in citations: doi:10.1515/9783111341996-023 doi:10.34734/FZJ-2025-01232
Abstract: AbstractSeveral studies have presented molecular and neurophysiological evidence establishing a connection between synaptic plasticity, specific cognitive functions, energy metabolism, and metabolic syndrome in certain brain areas. As altered plasticity and energy regulation have been associated with neuropsychiatric disorders, studying the neurochemical mechanisms behind neuronal plasticity and energy metabolism simultaneously may support groundbreaking neuroscientific and therapeutic interventions. A favorable approach for investigating neuronal plasticity and energy metabolism is with the use of transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique that enables the modulation of neuronal excitability and energy in humans. The modulation in excitability and energy is likely mediated by the γ-aminobutyric acid (GABA), which is a potent inhibitor, and high-energy phosphates. Another well-established, non-invasive technique allowing the in vivo examination of the human brain and its functions is magnetic resonance spectroscopy (MRS). MRS is frequently used to quantify the concentration changes of various metabolites at the cellular level in the brain. Although proton-based measurements continue to be the standard, advancements in MRS methodologies and MR hardware have led to the ability to measure variations in neurotransmitters and high-energy phosphates using both proton and phosphorus MRS simultaneously. Owing to the complementary features of both tDCS and MRS, the simultaneous acquisition of data using both modalities offers a promising approach for gathering paired information concerning adaptive synthesis and energy consumption in both healthy and pathologically altered brains. This technique enables access to profound insights into the regulation of brain functions and to model the biochemical plasticity of the motor cortex.
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